Кто читает:: Кафедра фундаментальной математики (Факультет информатики, математики и компьютерных наук (Нижний Новгород))

Статус:: Курс обязательный

Когда читается:: 1-й курс, 2 модуль

Abstract

The course "Selected Chapters in Cell Biology" covers key aspects of cell biology, focusing on the specificity of cells from various groups of eukaryotes, characteristics of membrane structure and function, intercellular signaling processes, thermodynamic foundations of life, regulation of the cell life cycle, mechanisms for storing and implementing genetic information, as well as the perception of physical fields and radiation by living organisms.

Learning Objectives

The purpose of the course is to gain knowledges of the cell biology

Expected Learning Outcomes

A student knows main types of cells, main organoids of cells, their functions.
A student knows main types of cells signaling, types of receptors and reaction times.
A student knows definition and conditions of homeostasis, metabolic map, Gibbs energy, ways ud energy transformation. A student knows about mathematical modeling in bioenergetics
A student knows main oscillating processes in organisms and cells, base of synthetic biology.
A student knows a modern ideas about the mechanisms of the emergence of new genes
A student knows principle of perception of electromagnetic waves of the radio frequency range by organisms, the risks of EM pollution of the environment
A student classify main types of cells
A student describes main organoids of cells
A student explains functioning of organoids
A student describes lipid bilayer biophysics
A student classifies transmembrane transport types
A student describes types of interactions
A student explains allosteric properties of macromolecular structures
A student can build dynamic models of polyenzymatic systems
A student can present enzymology data
A student describes gene expression stages
A student can build models of intergenic interactions
A student describes cell signaling types
A student can integrate receptor systems in models of gene regulation
A student explains cytoskeleton principles
A student describes molecular pathology mechanisms of prion diseases
A student can build dynamical models of cytosceletal physiology and pathology
A student describes cell cycle phases
A student explains checkpoints principles
A student describes main types of protein modifications behind cell cycle regulation
A student explains cell migration mechanisms
A student describes transcellular transport types
A student can build models of migrating cells
A student can build models of drug absorption through polar cells monolayers
A student describes types of cell biology data and typical workflows
A student can open, modify and analize main types of cell biology data: microscopy imaging, sequences and mass-spectra of proteins

Course Contents

The Cell as a System
Membranes
Molecular interactions
Enzyme kinetics
Gene expression
Cell signalling
Cytosckeleton
Cell cycle
Cell migration
Data types

Assessment Elements

Answering at least two questions regarding course topics on each seminar
Answering at least two questions regarding course topics on each seminar
Modern approaches and existing projects/platforms for mathematical simulation of the hole cell
Cellular or subcellular mechanism model of a data analysis workflow in KNIME

Interim Assessment

2026/2027 2nd module
0.4 * Cellular or subcellular mechanism model of a data analysis workflow in KNIME + 0.2 * Answering at least two questions regarding course topics on each seminar + 0.2 * Answering at least two questions regarding course topics on each seminar + 0.2 * Modern approaches and existing projects/platforms for mathematical simulation of the hole cell

Bibliography

Recommended Core Bibliography

9781284104516 - Jocelyn E. Krebs; Elliott S. Goldstein; Stephen T. Kilpatrick - Lewin's GENES XII, 12th ed. - 2017 - Jones & Bartlett Learning - http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1491538 - nlebk - 1491538
Author(s Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, & Publisher W. H. Freeman. (2006). Text Book(s) Title Molecular Cell Biology. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.701535BE
Cell biology : a short course, , 2022
Cell signalling, Hancock, J. T., 2017
Molecular cell biology, , 2016
Review questions on cell biology and genetics for students : учебно-методическое пособие / N. S. Abdukaeva, N. S. Kosenkova, Т. I. Gracheva [и др.]. — Санкт-Петербург : СПбГПМУ, 2019. — 32 с. — ISBN 978-5-907065-95-6. — Текст : электронный // Лань : электронно-библиотечная система. — URL: https://e.lanbook.com/book/174468 (дата обращения: 00.00.0000). — Режим доступа: для авториз. пользователей.

Recommended Additional Bibliography

9781439848890 - Eren, Halit; Webster, John G. - Measurement, Instrumentation, and Sensors Handbook : Spatial, Mechanical, Thermal, and Radiation Measurement, Second Edition - 2016 - CRC Press - https://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=694516 - nlebk - 694516
Genes and the agents of life : the individual in the fragile sciences, biology, Wilson, R. A., 2005

Authors

Stankevich Nataliia Vladimirovna
Bagaev Andrei Vladimirovich

Магистерская программа «Математика»

Адрес:

Selected Chapters of Cell Biology

Course Syllabus